As one might guess Paul was a man deeply connected to the Spirit of God. Not only connected and knowledgeable, Paul lived his live through and by the lead of the Holy Spirit. In this chapter of Acts we find the Spirit directing his very steps. Paul wants to go one place and the Spirit won't let him. So Paul yields to the spirit.
So what are the results of Paul yielding? Read on in the chapter and Paul is in jail. Wait a cotton picking minute. Paul does what he should by yielding to the Spirit and his reward is jail? Even there Paul is at God's work sharing the Gospel of Jesus. While most of us would be complaining about where we were after following God, Paul is busy saving souls.
Often we confuse life in the Spirit with life being easy. There is a dangerous tendency to think as long as we are following God things will be jut fine. Likewise we think if we are experiencing hard times, that we are not living by the Spirit of God. I find when I am living in the Spirit, more often than not life becomes a little more difficult. The true measure of living in the Spirit is not speaking in tongues, it is not having favor with everyone, it is not having everything go smooth. The true measure is found following God first in all circumstances, presenting Jesus Christ.